Manufacturing and standardizing allergen vaccines

Allergen vaccines are complex biologic mixtures in which standardization is essential to ensure efficacy and safety in allergic diagnosis and therapy. Statistically, a patient's IgE will bind to some allergens more frequently than others, thereby defining major allergens. All allergens are proteins and all soluble proteins are potential allergens. For major allergens, micr ograms are the useable measure for optimal clinical maintenance doses. Reco mbinant allergens are likely to replace natural allergens in the future.