Diethylene glycol acrylate-n-vinyl pyrrolidone copolymer resins for bone cement applications

Biodegradable and injectable monomer diethylene glycol acrylate (DGA) and d iethylene glycol acrylate-n-vinyl pyrrolidone (DGA-VP) blends have been pre pared and evaluated their suitability for bone cement applications. Studies on the setting of the monomer DGA and the blend DGA-VP have been carried o ut using a free radical initiator. Lower setting time is observed with the monomer in comparison with that of the blend. The degradation of cured PDGA and P(DGA-VP) polymeric materials has been evaluated in simulated physiolo gical fluids. Studies on degradation in hydrolytic and oxidative media reve al faster degradation during initial period of aging followed by slower and steady state degradation. br vitro degradation studies show more hydrolyti c degradation in PDGA while both hydrolytic and oxidative degradation in P( DGA-VP) in comparison to that of PDGA. Also, the biocompatible comonomer (V P) enhances biodegradation of aliphatic polyester PDGA.