The eight human herpesviruses can produce a broad spectrum of diseases in t
he Liver. The immunocompromised host is particularly susceptible to hepatic
manifestations of herpesvirus disease. Cytomegalovirus is the most common
opportunistic pathogen. The initial clinical presentation of hepatic herpes
virus infection may be subtle or nonspecific. Maintaining a high index of s
uspicion and immediately performing liver biopsy to document viral replicat
ion (alpha and beta herpesviruses) or the outgrowth of infected cells (gamm
a herpesviruses) can lead to lifesaving therapeutic interventions.