The liver is a common site of pathology in HIV-infected patients. In patien
ts with controlled HIV and minimal immunosuppression, infection with hepati
tis viruses is common owing to the risk factors of sexual transmission or p
arenteral drug use. In patients with AIDS, the liver is a common site of ly
mphohematogenous dissemination of several infectious pathogens. A thorough
diagnostic approach will lead to a diagnosis of most hepatobiliary processe
s. A sense of futility surrounding therapeutic treatment of hepatic disease
, including viral hepatitis, is unwarranted because treatment of the underl
ying HIV and hepatic process may improve the quality of life and longevity
of these patients.