Another case of transfusion-related lung injury due to anti-HNA-3a (-5b)

Following a literature review, we describe a fourth case of transfusion-rel ated lung injury (TRALI) due to a leukocyte antibody with anti-HNA-3a (-5b) specificity. The patient, a 72-year-old male, was admitted to hospital for surgery following an abdominal aortic aneurysm. Postoperatively, after tra nsfusion of 2 units of packed red blood cells (PRBC) and 2 units of fresh f rozen plasma (FFP) concentrate, the patient developed typical signs of TRAL I. Anti-HNA-3a was found in the serum of 1 of the 2 FFP units. The female d onor had no transfusion history, but had had 2 pregnancies more than 35 yea rs previously.