Measurement of hepatic perfusion with dynamic computed tomography - Assessment of normal values and comparison of two methods to compensate for motion artifacts
Tr. Bader et al., Measurement of hepatic perfusion with dynamic computed tomography - Assessment of normal values and comparison of two methods to compensate for motion artifacts, INV RADIOL, 35(9), 2000, pp. 539-547
Citations number
34
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
RATIONALE AND OBJECTIVES. TO assess normal values of hepatic perfusion by d
ynamic, single-section computed tomography, to compare two methods of data
processing (a smoothing with a fitting procedure), and to evaluate the infl
uence of motion artifacts.
METHODS. Twenty-five volunteers with no history or suspicion of liver disea
se were examined (age range, 32.8-81.1 years). All examinations were subjec
tively ranked into groups 1 through 3 according to the degree of motion art
ifacts (negligible, moderate, severe). All data were processed with a smoot
hing procedure and a pharmacokinetic fitting procedure (TopFit), The arteri
al, portal venous, acid total hepatic perfusion; the hepatic perfusion inde
x (HPI); and the arterial/portal venous ratio (A/P ratio) were calculated w
ith both procedures.
RESULTS. Mean hepatic perfusion, as assessed with the fitting procedure and
the smoothing procedure, respectively, was as follows: arterial, 0.20 and
0.22 mL.min(-1).mL(-1); portal venous, 1.02 and 1.24 mL.min(-1).mL(-1); tot
al perfusion, 1.22 and 1.47 mL.min(-1).mL(-1); HPI, 16.4% and 15.4%; and A/
P ratio, 0.20 and 0.19. The differences were significant for the portal ven
ous and total hepatic perfusion. The portal venous and total hepatic perfus
ion values showed significant differences between group 1 and groups 2 and
3 for both procedures. HPI and the A/P ratio showed no significant differen
ces at all.
CONCLUSIONS. Motion artifacts and the type of data processing influence the
assessment of the arterial, portal venous, and total hepatic perfusion but
do not influence measurement of the HPI and the A/P ratio.