B-5354a, b and c, new sphingosine kinase inhibitors, produced by a marine bacterium; Taxonomy, fermentation, isolation, physico-chemical properties and structure determination

In the course of our screening for inhibitors of sphingosine kinase, we fou nd a series of active compounds in a culture broth of a novel marine bacter ium, SANK 71896. The structures of the compounds, named B-5354a, b and c, w ere elucidated by a combination of spectroscopic analyses to be new esters of 4-amino-3-hydroxybenzoic acid with long-chain unsaturated alcohols. B-53 54a, b and c inhibit sphingosine kinase activity with IC50 values of 21, 58 and 38 mu M, respectively.