Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040 I. Taxonomy, fermentation, isolation and biological activities

Authors
Schimana, J Fiedler, HP Groth, I Sussmuth, R Beil, W Walker, M Zeeck, A
Citation
J. Schimana et al., Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040 I. Taxonomy, fermentation, isolation and biological activities, J ANTIBIOT, 53(8), 2000, pp. 779-787
Citations number
15
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
53
Issue
8
Year of publication
2000
Pages
779 - 787
Database
ISI
SICI code
0021-8820(200008)53:8<779:SNCAAP>2.0.ZU;2-5
Abstract
Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were de tected in the mycelium extract of Streptomyces antibioticus Tu 6040 by HPLC -diode-array and HPLC-electrospray-mass-spectrometry screening. The compoun ds show antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.