Diheteropeptin, a novel substance with TGF-beta-like activity, produced bya fungus, Diheterospora chlamydosporia II. Physico-chemical properties andstructure elucidation

Authors
Masuoka, Y Shin-Ya, K Furihata, K Matsumoto, H Takebayashi, Y Ngai, K Suzuki, K Hayakawa, Y Seto, H
Citation
Y. Masuoka et al., Diheteropeptin, a novel substance with TGF-beta-like activity, produced bya fungus, Diheterospora chlamydosporia II. Physico-chemical properties andstructure elucidation, J ANTIBIOT, 53(8), 2000, pp. 793-798
Citations number
7
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
53
Issue
8
Year of publication
2000
Pages
793 - 798
Database
ISI
SICI code
0021-8820(200008)53:8<793:DANSWT>2.0.ZU;2-Y
Abstract
The structure of diheteropeptin (1), a TGF-beta-like active substance from Diheterospora clamydosporia in Q58044, was determined to be a new cyclotetr apeptide, cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(2S,8R,9R)-2- amino-8,9-dihydroxydecanoyl-] by NMR, mass spectrometric and chemical studi es.