The human desipramine-sensitive noradrenaline transporter and the importance of defined amino acids for its function

1 This article gives a short overview of the physiology, pharmacology and t he molecular biology of the human Na+/Cl--dependent noradrenaline transport er (hNAT) and its gene. 2 Furthermore, naturally occurring variants of the hNAT are described and n ew results obtained through site-directed mutagenesis of the hNAT are prese nted, which increase our understanding about structural domains and amino a cids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.