Antimicrobial activities of secondary metabolites produced by endophytic fungi from Spondias mombin

We performed a search for bioactive compounds produced by fungal endophytes from Spondias mombin (Anacardiaceae). Culture broth extracts of Guignardia sp. Phomopsis sp. and Pestalotiopsis guepinii were separated by chromatogr aphic methods and tested for biological activities. The crude extracts of t hese endophytes were tested against fourteen organisms, including actinomyc etes, Gram-negative and Gram-positive bacteria. yeast, and filamentous fung i. All fungal extracts inhibited actinomycete growth. Guignardia sp. was al so active against Escherichia coli, Staphylococcus aureus, Saccharomyces ce revisiae, Geotrichum sp., and Penicillium canadensis. Culture extracts of P . guepinii were active against S, cerevisae, while strains of Phomopsis sp. showed a pronounced antifungal effect against Cladosporium elatum, Mycotyp ha sp. and S. cerevisae.