Adherence characteristics and susceptibility to antimicrobial agents of Staphylococcus aureus strains isolated from skin infections and atopic dermatitis

We examined the adherence characteristics and susceptibility to various ant imicrobial agents of 130 strains of Staphylococcus aureus isolated from inf ective skin lesions and 135 strains of S. aureus isolated from non-infectiv e eczematous lesions of atopic dermatitis (AD) patients. The isolation rate of methicillin-resistant S. aureus (MRSA) was 27.7% in strains from clinic al sources excluding AD and 31.1% in those from AD. Coagulase type II strai ns were most frequently observed in MRSA strains isolated from all sources excluding AD, and coagulase type III strains were most frequently observed in those isolated from AD. We proposed that antimicrobial treatment for AD patients should be carefully designed to prevent MRSA infection. Plasma coa gulation ability was lowest in S. aureus strains isolated from abscesses, s uggesting that the lower production of fibrin observed in abscesses may ass ist the infiltration of neutrophils into skin tissues and that a decrease i n plasma coagulation ability may enable abscess formation. Adherence to pol ypropylene tubes with slime production was most evident in S. aureus strain s isolated from felon and least evident in those isolated from cellulitis a nd lymphangitis. Tube adherence was characteristic of the S. aureus strains attached to superficial skin tissues, but not necessarily for strains that had infiltrated the deep skin tissues. Fusidic acid demonstrated significa nt antimicrobial activity against the MRSA strains, but rifampicin was the strongest antimicrobial agent. (C) 2000 Elsevier Science Ireland Ltd. All r ights reserved.