Strong association of interleukin-6 and lipopolysaccharide-binding proteinwith severity of adverse reactions after diethylcarbamazine treatment of microfilaremic patients

Citation
M. Haarbrink et al., Strong association of interleukin-6 and lipopolysaccharide-binding proteinwith severity of adverse reactions after diethylcarbamazine treatment of microfilaremic patients, J INFEC DIS, 182(2), 2000, pp. 564-569
Citations number
30
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
JOURNAL OF INFECTIOUS DISEASES
ISSN journal
00221899 → ACNP
Volume
182
Issue
2
Year of publication
2000
Pages
564 - 569
Database
ISI
SICI code
0022-1899(200008)182:2<564:SAOIAL>2.0.ZU;2-F
Abstract
To assess the involvement of inflammatory mediators in the development of a dverse reactions in filarial patients undergoing treatment, 29 microfilarem ic subjects were treated with diethylcarbamazine (DEC). Before and at seria l time points after initiation of treatment, plasma levels of inflammatory mediators and DEC were measured, and adverse reactions were recorded. Patie nts experienced no or mild, moderate, or severe adverse reactions. Increasi ng pretreatment microfilarial counts were associated with escalating severi ty of adverse reactions. Plasma concentrations of DEC were not different am ong patients suffering from varying degrees of illness. Interleukin (IL)-6, IL-10, lipopolysaccharide-binding protein (LBP), and soluble tumor necrosi s factor receptors (sTNF-Rs) increased after treatment. IL-6 and LBP, howev er, showed the strongest association with adverse reactions. Increasing lev els of these molecules were closely correlated with the mounting severity o f adverse reactions, which raises the possibility that they play an importa nt role in systemic inflammation that arises after DEC treatment of filaria l patients.