Alkaloids from Delphinium staphisagria

Three new diterpenoid alkaloids, isoazitine (1), 19-oxodihydroatisine (2), and 22-O-acetyl-19-oxodihydroatisine (3), and eight known alkaloids-azitine (4), dihydroatisine (5), delphinine, neoline, bullatine C (14-acetylneolin e), chasmanine, 14-acetylchasmanine, and the quaternary base atisinium chlo ride (7)- were isolated from the aerial parts of Delphinium staphisagria. S tructures of the new alkaloids were established mainly by 1D and 2D NMR spe ctroscopy, including H-1 COSY, HMQC, HMBC, and ROESY. The H-1 and C-13 NMR data for alkaloids 4 and 5 are also reported.