C-18 hydroxylation of gibberellins

Authors
Mander, LN Thomson, RJ
Citation
Ln. Mander et Rj. Thomson, C-18 hydroxylation of gibberellins, J CHEM S P1, (17), 2000, pp. 2893-2894
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14704358 → ACNP
Issue
17
Year of publication
2000
Pages
2893 - 2894
Database
ISI
SICI code
1470-4358(2000):17<2893:CHOG>2.0.ZU;2-O
Abstract
A protocol for the hydroxylation of the 18-methyl group in gibberellins has been developed, as demonstrated by the successful synthesis of 18-hydroxy GA(4) methyl ester by means of a tandem process involving the conjugate add ition of alkoxide to the alpha-methylene lactone moiety of a ring A-seco-gi bberellin followed by an intramolecular aldol reaction.