N. Muratakamiya et al., TYPES OF MUTATIONS INDUCED BY GLYOXAL, A MAJOR OXIDATIVE DNA-DAMAGE PRODUCT, IN SALMONELLA-TYPHIMURIUM, Mutation research, 377(1), 1997, pp. 13-16
We have analyzed the types of mutations induced by glyoxal, a major ox
idative DNA-damage product, in Salmonella typhimurium. A set of six st
rains, TA7001 to TA7006, was used to detect base-pair substitutions, a
nd the TA98 strain was employed to detect frameshift mutations. Glyoxa
l did not induce mutations at A:T base pairs. The majority of the muta
tions induced by glyoxal were base-pair substitutions at G:C base pair
s, and a small level of frameshift mutations was detected in the TA98
strain.