HUMAN RAD52 PROTEIN PROMOTES SINGLE-STRAND DNA ANNEALING FOLLOWED BY BRANCH MIGRATION

Authors
REDDY G GOLUB EI RADDING CM
Citation
G. Reddy et al., HUMAN RAD52 PROTEIN PROMOTES SINGLE-STRAND DNA ANNEALING FOLLOWED BY BRANCH MIGRATION, Mutation research, 377(1), 1997, pp. 53-59
Citations number
35
Categorie Soggetti
Genetics & Heredity",Biology,"Biothechnology & Applied Migrobiology
Journal title
Mutation research → ACNP
ISSN journal
00275107
Volume
377
Issue
1
Year of publication
1997
Pages
53 - 59
Database
ISI
SICI code
0027-5107(1997)377:1<53:HRPPSD>2.0.ZU;2-4
Abstract
In the yeast, Saccharomyes cerevisiae, the Rad52 gene is important for both mitotic and meiotic recombination. Homologs of the Rad52 gene ha ve been identified in several eukaryotic organisms, ranging from yeast to man. As reported here, human Rad52 protein binds to both single- a nd double-stranded DNA; and acting on a pair of single-stranded and pa rtially duplex substrates it promotes annealing of complementary stran ds of DNA, which is followed by branch migration.