Improved high-resolution diffusion filtered H-1 MAS NMR

Application of pulsed field gradient diffusion edited NMR has been successf ully used for the analysis of solid-phase resin. A comparison between the L ED and bipolar LED pulse sequence is presented. Compounds that were not cov alently attached to the resin, including the solvent system, can be effecti vely attenuated using the bipolar LED sequence without signal distortion. T he resulting proton spectrum can then be interpreted as compounds that were attached to the solid support. This methodology has also been demonstrated with the use of the bipolar LED edited COSY sequence in which COSY correla tions from only the attached compounds are observed. Copyright (C) 2000 Joh n Wiley & Sons, Ltd.