The purpose of the study is to further assess the usefulness of short TI (t
ime to inversion) recovery (STIR) magnetic resonance imaging (MRI) in detec
ting denervation of skeletal muscle compared to needle electromyography (EM
G). Ninety subjects with clinical evidence of peripheral nerve injury or ra
diculopathy underwent STIR MRI and EMG of the affected limb. In 74 (82%) of
these subjects, a positive correlation was found between STIR MRI and EMG
(P < 0.009). STIR MRI has a relative sensitivity of 84% and specificity of
100% for detecting denervation. A subset of 28 subjects underwent quantitat
ive assessments of signal intensity ratio (SIR) from the STIR MRI, The rank
order correlation coefficient between the SIR and abnormal spontaneous act
ivity on EMG was 0.70 (P < 0.001), Increased signal intensity on STIR MRI c
orresponds closely with spontaneous activity on EMG in denervated muscle. A
lthough less sensitive than EMG in detecting muscle denervation, STIR MRI m
ay be a useful adjunctive diagnostic tool in this setting. (C) 2000 John Wi
ley & Sons, Inc.