Involvement of G-protein-activated inwardly rectifying K+ (GIRK) channels in opioid-induced analgesia

Authors
Ikeda, K Kobayashi, T Kumanishi, T Niki, H Yano, R
Citation
K. Ikeda et al., Involvement of G-protein-activated inwardly rectifying K+ (GIRK) channels in opioid-induced analgesia, NEUROSCI RE, 38(1), 2000, pp. 113-116
Citations number
21
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE RESEARCH
ISSN journal
01680102 → ACNP
Volume
38
Issue
1
Year of publication
2000
Pages
113 - 116
Database
ISI
SICI code
0168-0102(200009)38:1<113:IOGIRK>2.0.ZU;2-O
Abstract
To investigate the role of G-protein-activated inwardly rectifying K+ (GIRK ) channels in opioid-induced analgesia, we compared the effects of opioids in wild-type and weaver mutant mice having mutant GIRK channels. In the tai l-flick and hot-plate tests, weaver mutant mice displayed significantly low er analgesia after either morphine or (-)-U-50488 administration. These fin dings suggest that GIRK channel activation is important in the induction of analgesia by opioids. (C) 2000 Elsevier Science Ireland Ltd and the Japan Neuroscience society. All rights reserved.