Drug therapy in Behcet's disease

Behcet's disease is one of the most difficult forms of uveitis to treat. Va riety in disease presentation and severity, as well as regional differences in standard of care, demand a tailor-made approach. Anterior segment infla mmation generally responds to topical corticosteroids. However, the onset o f posterior segment inflammation usually requires the advancement of treatm ent to periocular injections and/or oral administration of corticosteroids. Cyclosporin, either alone or in combination with corticosteroids, is consi dered in refractory patients. Other immunosuppressive drugs, such as azathi oprine and chlorambucil, may be considered in difficult cases. Finally, pre liminary results suggest efficacy with the immunomodulatory agent interfero n alfa, although further clinical trials are necessary to evaluate safety a nd efficacy.