Correlation between static automated and scanning laser entoptic perimetryin normal subjects and glaucoma patients

Objective: To compare the effectiveness of scanning laser entoptic perimetr y with static automated perimetry as a noninvasive instrument for screening for glaucomatous damage in visually asymptomatic subjects within the centr al 60 degrees (diameter) of vision. Design: A masked cross-sectional study comparing entoptic perimetry to achr omatic threshold perimetry, Participants: Twenty-three subjects and controls from the Sharp Flees-Steal y Hospital and the Shiley Eye Center at the University of California, San D iego. Testing: Virtual reality-based entoptic perimetry was compared with achroma tic threshold perimetry, Main Outcome Measures: For each testing session, we compared the presence o f a disturbance in the entoptic perimetry stimulus with the presence of def ects in visual function as measured by Humphrey automated visual field peri metry. Results: Scanning laser entoptic perimetry reasonably estimates the overall visual field loss for moderate-to-severe scotomas as measured by the patte rn deviation in standard visual field perimetry. Scanning laser entoptic pe rimetry has a sensitivity from 27% to 90% and a specificity from 50% to 100 % for screening moderate-to-severe visual field defects caused by glaucoma within the central 60 degrees diameter of vision. Conclusions: Scanning laser entoptic perimetry may be an effective and inex pensive screening test in hospitals and community clinics for diagnosing vi sual field loss caused by glaucoma. Ophthalmology 2000;107: 1693-1701 (C) 2 000 by the American Academy of Ophthalmology.