Effect of mometasone furoate by topical application on allergic rhinitis model in rats

The effects of mometasone furoate on experimental allergic rhinitis in rats were studied in comparison with that of fluticasone propionate. Topical ap plication of both drugs inhibited dose-dependently the increase of nasal sy mptoms (sneezing and nasal rubbing) after antigen challenge to the nasal ca vity of actively sensitized rats. Mometasone furoate and fluticasone propio nate at concentrations of 0.01 or 0.1% significantly inhibited both nasal r ubbing and sneezing 1 h after topical application of both drugs. The relati ve potencies of mometasone furoate in nasal rubbing and sneezing compared t o fluticasone propionate were 5.01 and 6.87, respectively. Mometasone furoa te (0.02%) and fluticasone propionate (0.1%) significantly inhibited the in crease of antigen-induced nasal rubbing even 6 h after topical application, indicating that both drugs have a long-lasting effect. Copyright (C) 2000 S. Karger AG, Basel.