Chemical analysis and antimicrobial studies on three species of Ferulago from Greece

The chemical composition of the essential oils of the flowering parts and o f the hexane extracts of the leaves, of three species of the genus Ferulago (Apiaceae) from Greece, i.e., F. thyrsiflora, F. sylvatica and F. nodosa, was analysed by GC and GC-MS. Manoyl oxide isomers and lupanine, were ident ified in the hexane extracts of F: thyrsiflora. Dillapiole, was identified in all hexane extracts. Ent-3 beta-hydroxy-13-epi-manoyl oxide was identifi ed and isolated from the essential oil of F. thyrsiflora. All these compoun ds are new reports for the genus Ferulago and are useful chemotaxonomic mar kers. Chemical data of F. thyrsiflora is presented for the first time. The essential oils and the extracts were investigated for their antimicrobial a ctivity against Gram-positive and Gram-negative microorganisms.