Isoflavonoids from Pueraria mirifica and their estrogenic activity

Authors
Chansakaow, S Ishikawa, T Sekine, K Okada, M Higuchi, Y Kudo, M Chaichantipyuth, C
Citation
S. Chansakaow et al., Isoflavonoids from Pueraria mirifica and their estrogenic activity, PLANTA MED, 66(6), 2000, pp. 572-575
Citations number
20
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
66
Issue
6
Year of publication
2000
Pages
572 - 575
Database
ISI
SICI code
0032-0943(200008)66:6<572:IFPMAT>2.0.ZU;2-U
Abstract
Nine isoflavonoids including a new pterocarpene, puemiricarpene, were isola ted from the tuberous root of Pueraria mirifica (Leguminosae). The structur e of puemiricarpene was determined by spectroscopic means. Estrogenic activ ity of the isolated isoflavonoids was tested using MCF-7 human breast cance r cells. Moderate activity was observed for kwakhurin, a prenylated isoflav onoid.