Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells

Authors
Kuroda, M Mimaki, Y Sashida, Y Umegaki, E Yamazaki, M Chiba, K Mohri, T Kitahara, M Yasuda, A Naoi, N Xu, ZW Li, MR
Citation
M. Kuroda et al., Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells, PLANTA MED, 66(6), 2000, pp. 575-577
Citations number
13
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
66
Issue
6
Year of publication
2000
Pages
575 - 577
Database
ISI
SICI code
0032-0943(200008)66:6<575:FGFESA>2.0.ZU;2-Q
Abstract
The MeOH extract of Epimedium sagittatum was found to show neurite outgrowt h activity on cultured PC12h cells. Bioassay-guided fractionation of the Me OH extract yielded six prenylated flavonol glycosides, ikarisoside A (1), i carisid II (2), epimedoside A (3), icariin (4), epimedin B (5), and epimedo koreanoside-I (6) as the active ingredients.