RAD29 and RAD31, new genes of the yeast Saccharomyces cerevisiae involved in DNA repair control: Determining possible functions of these genes

Possible functions of previously described genes RAD29 and RAD31 involved i n DNA repair were determined by analyzing the interaction between these gen es and mutations in the genes of the three basic epistatic groups: RAD3 (nu cleotide excision repair), RAD6 (error-prone mutagenic repair system), RAD5 2 (recombination repair pathway), and also the apn1 mutation that blocks th e synthesis of major AP endonuclease (base excision repair). The results ob tained in these studies and the estimation of the capability for excision r epair of lesions induced by 8-metoxipsoralen and subsequent exposure to lon g-wavelength UV light in mutants for these genes led to the assumption that the RAD29 and RAD31 genes are involved in yeast DNA repair control.