The synthesis of a 5-HETE photoaffinity ligand

Authors
Saha, G Khanapure, SP Powell, WS Rokach, J
Citation
G. Saha et al., The synthesis of a 5-HETE photoaffinity ligand, TETRAHEDR L, 41(33), 2000, pp. 6313-6317
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
33
Year of publication
2000
Pages
6313 - 6317
Database
ISI
SICI code
0040-4039(20000812)41:33<6313:TSOA5P>2.0.ZU;2-U
Abstract
The design and synthesis of a photoaffinity ligand 26, targeted at the 5h-d h, was accomplished. The synthesis was effected by two new synthetic routes which focus on the omega-hydroxy 5-HETE derivative 12 as a pivotal synthon . Preliminary results show ligand 26 to be an excellent substrate for the 5 h-dh. (C) 2000 Elsevier Science Ltd. All rights reserved.