Synthesis of the C15-C27 fragment of the antitumor agent laulimalide

Authors
Dorling, EK Ohler, E Mulzer, J
Citation
Ek. Dorling et al., Synthesis of the C15-C27 fragment of the antitumor agent laulimalide, TETRAHEDR L, 41(33), 2000, pp. 6323-6326
Citations number
32
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
33
Year of publication
2000
Pages
6323 - 6326
Database
ISI
SICI code
0040-4039(20000812)41:33<6323:SOTCFO>2.0.ZU;2-M
Abstract
A stereocontrolled synthesis of the C15-C27 fragment of laulimalide is desc ribed. Key features are a divergent-convergent synthesis from (R)-glycidol, an interesting formation of a trisubstituted double bond via ring closing metathesis with Grubbs' ruthenium catalyst and a site selective protection of a syn-1,2-diol. (C) 2000 Elsevier Science Ltd. All rights reserved.