Rhodium-catalyzed enantioselective hydrogenation using chiral monophosphonite ligands

Authors
Reetz, MT Sell, T
Citation
Mt. Reetz et T. Sell, Rhodium-catalyzed enantioselective hydrogenation using chiral monophosphonite ligands, TETRAHEDR L, 41(33), 2000, pp. 6333-6336
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
33
Year of publication
2000
Pages
6333 - 6336
Database
ISI
SICI code
0040-4039(20000812)41:33<6333:REHUCM>2.0.ZU;2-H
Abstract
Surprisingly high enantioselectivities in the Rh-catalyzed hydrogenation of itaconic acid dimethyl eater and methyl-2-acetamido acrylate are observed upon using chiral monophosphonite ligands derived from binaphthol (ee up to 94%). Although appropriate chelating diphosphonites are more effective, th e easy modular synthesis of the chiral monophosphonites may allow for the o ptimization of a given asymmetric hydrogenation reaction. (C) 2000 Elsevier Science Ltd. All rights reserved.