Direct strand cleavage via furanyladenine formation in anaerobic photoirradiation of 5-bromouracil-containing oligonucleotides

Authors
Fujimoto, K Ikeda, Y Saito, I
Citation
K. Fujimoto et al., Direct strand cleavage via furanyladenine formation in anaerobic photoirradiation of 5-bromouracil-containing oligonucleotides, TETRAHEDR L, 41(33), 2000, pp. 6455-6459
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
33
Year of publication
2000
Pages
6455 - 6459
Database
ISI
SICI code
0040-4039(20000812)41:33<6455:DSCVFF>2.0.ZU;2-0
Abstract
The mechanism of direct strand cleavage induced by anaerobic irradiation of 5-bromouracil (U-Br)- containing DNA was investigated. The formation of an oligonucleotide fragment containing 3'-furanyladenine end like 5 was obser ved as a major photoproduct for the direct strand breaks. (C) 2000 Elsevier Science Ltd. All rights reserved.