Artificial holoenzymes for benzoin condensation using thiazolio-appended beta-cyclodextrin dimers

Authors
Ikeda, H Horimoto, Y Nakata, M Ueno, A
Citation
H. Ikeda et al., Artificial holoenzymes for benzoin condensation using thiazolio-appended beta-cyclodextrin dimers, TETRAHEDR L, 41(33), 2000, pp. 6483-6487
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
33
Year of publication
2000
Pages
6483 - 6487
Database
ISI
SICI code
0040-4039(20000812)41:33<6483:AHFBCU>2.0.ZU;2-7
Abstract
Artificial holoenzymes for benzoin condensation were synthesized using thia zolio-appended beta-cyclodextrin dimers. The dimer with an L-aspartic acid residue as a linker for connecting two beta-cyclodextrin units caused a 26- fold acceleration in the benzoin condensation, whereas the dimer with the l inker of a L-glutamic acid residue caused only a 7-fold acceleration, indic ating that the linker length of the dimer is an important factor in this ar tificial holoenzyme. (C) 2000 Elsevier Science Ltd, All rights reserved.