Protein C and protein S deficiencies are the most important risk factors associated with thrombosis in Chinese venous thrombophilic patients in Taiwan

The relative risks (odds ratio, OR) of various risk factors for venous thro mbophilia, including sex, antithrombin III, protein C (PC), protein S (PS) and plasminogen deficiencies, and C677T homozygous mutation of methylenetet rahydrofolate reductase gene were assessed using age matched (+/- 5 years) conditional logistic regression analysis in 116 Chinese venous thrombophili c patients (58 males; 58 females, mean age 47.5 +/- 17.7 [SD] years) and 12 5 healthy controls (67 males; 58 females, mean age 45.5 +/- 15.7 years). No ne of the patients had prothrombin G20210A and factor V Leiden mutation or an activated PC sensitivity ratio of less than 2, One hundred and five age- matched patients and 105 controls were entered in this analysis. Only PC an d PS deficiencies were significantly associated with increased risk for the development of thrombosis with an OR of 10.6 (95% confidence interval 2.3- 49.9, P = 0.0028) and 6.7 (2.7-16.5, P = 0.0001), respectively. The finding s of this study suggest that PC deficiency and PS deficiency are the most i mportant risk factors for thrombosis in Chinese venous thrombophilic patien ts. (C) 2000 Elsevier Science Ltd, All rights reserved.