Selamectin: a novel broad-spectrum endectocide for dogs and cats

Selamectin, 25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22,23-dihydro-5-(hy droxyimino)-avermectin B1 monosaccharide, is a novel endectocide with a uni que combination of efficacy and safety in dogs and cats following both oral and topical administration. The compound is active against fleas and ticks , intestinal hookworms and ascarids, and immature heartworms. Also it is we ll tolerated at higher dosages than 22,23-dihydroavermectin B1a (DHAVM) or milbemycin oxime in Collies, which is a breed known to exhibit idiosyncrati c sensitivity to avermectins. (C) 2000 Elsevier Science B.V. All rights res erved.