Combined use of cellulose acetate polymer and retrievable platinum coils for the thrombosis of cervical carotid aneurysms

Cellulose acetate polymer (CAP) solution is a new liquid embolic material, and it has been used clinically for the thrombosis of cerebral aneurysms. T he purpose of the study was to test a method of aneurysm treatment. In an e xperimental model, retrievable interlocking detachable coils (IDCs) were us ed to create an intraaneurysmal frame or prop and then CAP was injected int o 20 experimentally induced canine cervical aneurysms. Intraaneurysmal thro mbosis was induced 1 week after aneurysm creation. Complete thrombosis was attempted in 12 aneurysms, and partial thrombosis was attempted in 4. Four other aneurysms served as controls. Follow-up angiography was performed for up to 8 weeks, and with the exception of 4 aneurysms, which were kept for a a-year long-term follow-up study, the aneurysms were then harvested for h istological examination. Thrombosis was successfully achieved in all cases except for 2 enlarged aneurysms that were initially partially thrombosed. N o thromboembolism to distal vessels was observed. No compaction or shift of the CAP-IDC complex occurred even after 2 years. Histologically, CAP and I DCs conformed to the massive thrombotic complex without any fragmentation. By creating a frame or prop with retrievable microcoils, we were able to in ject the CAP implies a comparison safely and precisely than has been previo usly reported. Our findings suggest that this method will be useful for the treatment of cerebral aneurysms.