This study investigated the value of collateral informant reports of substa
nce use for patients with current bipolar disorder and substance dependence
. We collected collateral informant reports on 132 occasions for 32 patient
s and found a high level of agreement between collateral reports and self-r
eport/urine screen data (75.0%). In only 3 instances did collateral informa
nts report substance use for patients who denied use and had negative urine
screens. Frequency of contact between informants and patients was associat
ed significantly with the level of agreement. These findings suggest that o
btaining collateral informant data when studying this population may be of
limited value.