Simultaneous quantification of ceftazidime and pyridine, its main degradation product, by highperformance liquid chromatography

Authors
Favetta, P Janoly, A Allombert, C Breysse, C Guitton, J Bureau, J
Citation
P. Favetta et al., Simultaneous quantification of ceftazidime and pyridine, its main degradation product, by highperformance liquid chromatography, ANAL LETTER, 33(12), 2000, pp. 2465-2475
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
ANALYTICAL LETTERS
ISSN journal
00032719 → ACNP
Volume
33
Issue
12
Year of publication
2000
Pages
2465 - 2475
Database
ISI
SICI code
0003-2719(2000)33:12<2465:SQOCAP>2.0.ZU;2-K
Abstract
A high performance liquid chromatographic method for the simultaneous assay of ceftazidime and pyridine, the principal degradation product of ceftazid ime, is described. The method was fully validated in terms of recovery, lin earity, selectivity and precision. An application was done on stability of ceftazidime at 40 mg.mL(-1) in infusion solutions 0.9% NaCl and 5% glucose on 24 hours in ambulatory infusion device. Quantification results of pyridi ne were more linear and accurate than ceftazidime. Pyridine was a good labe l in ceftazidime stability studies.