Simultaneous determination of valsartan and hydrochlorothiazide in tabletsby high-performance liquid chromatography

Authors
Carlucci, G Di Carlo, V Mazzeo, P
Citation
G. Carlucci et al., Simultaneous determination of valsartan and hydrochlorothiazide in tabletsby high-performance liquid chromatography, ANAL LETTER, 33(12), 2000, pp. 2491-2500
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
ANALYTICAL LETTERS
ISSN journal
00032719 → ACNP
Volume
33
Issue
12
Year of publication
2000
Pages
2491 - 2500
Database
ISI
SICI code
0003-2719(2000)33:12<2491:SDOVAH>2.0.ZU;2-L
Abstract
A method for the simultaneous determination of valsartan and hydrochlorothi azide in tablets is described. The procedure, based on the use of reversed- phase high-performance liquid chromatography, is linear in the concentratio n range 5.0-10.0 mu g ml(-1) for valsartan and 0.5-2.0 mu g ml(-1) for hydr ochlorothiazide, is simple and rapid and allows accurate and precise result s. The limit of detection was 1.0 mu g ml(-1) for valsartan and 0.05 mu g m l(-1) for hydrochlorothiazide.