We have developed a model which aims to reproduce observational data of man
y kinds related to cosmic-ray (CR) origin and propagation: direct measureme
nts of nuclei, antiprotons, electrons and positrons, gamma-rays, and synchr
otron radiation. Our main results include evaluation of diffusion/convectio
n and reacceleration models, estimates of the halo size, calculations of th
e interstellar positron and antiproton spectra, evaluation of alternative h
ypotheses of nucleon and electron interstellar spectra, and computation of
the Galactic diffuse gamma-ray emission. Recently our CR propagation code h
as been generalized to include fragmentation networks of arbitrary complexi
ty. The code can now provide an alternative to leaky-box calculations for f
ull isotopic abundance calculations and has the advantage of including the
spatial dimension which is essential for radioactive nuclei. Preliminary pr
edictions for sub-Fe/Fe, Be-10/Be-9 and Al-26/Al-27 are presented in antici
pation of new experimental isotopic data. We show that combining informatio
n from classical CR studies with gamma-ray and other data leads to tighter
constraints on CR origin and propagation.