Advanced technology and the desire to explore space have resulted in increa
singly longer manned space missions. Long Duration Space Flights (LDSF) hav
e provided a considerable amount of scientific research on the ability of h
umans to adapt and function in microgravity environments. In addition, stud
ies conducted in analogous environments, such as winter-over expeditions in
Antarctica, have complemented the scientific understanding of human perfor
mance in LDSF. These findings indicate long duration missions may take a to
ll on the individual, both physiologically and psychologically, with potent
ial impacts on performance. Significant factors in any manned LDSF are habi
tability, workload and performance. They are interrelated and influence one
another, and therefore necessitate an integrated research approach. An int
egral part of this approach will be identifying and developing tools not on
ly for assessment of habitability, workload, and performance, but also for
prediction of these factors as well. In addition, these tools will be used
to identify and provide countermeasures to minimize decrements and maximize
mission success. The purpose of this paper is to identify research goals a
nd methods for the International Space Station (ISS) in order to identify c
ritical factors and level of impact on habitability, workload, and performa
nce and to develop and validate countermeasures. Overall, this approach wil
l provide the groundwork for creating an optimal environment in which to li
ve and work onboard ISS as well as preparing for longer planetary missions.