(-)-Multiflorine (1), which was isolated from leguminous plants, produced a
hypoglycemic effect when administered to mice with streptozotocin-induced
diabetes. (-)-Multiflorine has an enaminone type conjugation on the A-ring,
which is unusual in lupine alkaloids, Proceeding on the assumption that th
e A-B ring is responsible for the activity, several compounds bearing quino
lizidin-2-one were synthesized and their hypoglycemic effects were examined
, The hypoglycemic effect of (7R*,9aS*)-7-phenyl-octahydroquinolizin-2-one
was approximately 4 times stronger than that of (-)-multiflorine measured b
y oral glucose tolerance test in normal mice. This result indicates that co
mpounds possessing the quinolizidin-2-one ring system as the basic structur
e may be possible lead compounds for a new type of diabetes drug.