Ms. Rodgers et Jl. Mccall, Surgery for colorectal liver metastases with hepatic lymph node involvement: a systematic review, BR J SURG, 87(9), 2000, pp. 1142-1155
Background: Liver resection for colorectal metastases is the only known tre
atment associated with long-term survival; extrahepatic disease is usually
considered a contraindication to such treatment. However, some surgeons do
not regard spread to the hepatic lymph nodes as a contraindication provided
that these nodes can be excised adequately. A systematic review of the lit
erature was undertaken to address this issue.
Methods: An electronic search using Medline, Cancerlit and Embase databases
was performed for studies reporting liver resection for colorectal metasta
ses from 1964 to 1999. Data were extracted from papers reporting outcome fo
r patients with positive hepatic nodes and analysed according to predetermi
ned criteria.
Results: Fifteen studies were identified that gave survival data on 145 nod
e-positive patients. Five patients were reported to have survived 5 years a
fter liver resection; one was disease free, two had recurrent disease and t
he disease status was not described in the remaining two. Five studies cont
aining 83 patients specified a formal lymph node dissection as part of the
surgical procedure and four of the five node-positive 5-year survivors were
from these studies.
Conclusion: There are few 5-year survivors after liver resection, with or w
ithout lymph node dissection, for colorectal hepatic metastases involving t
he hepatic lymph nodes.