Left main coronary artery disease in adults younger than 50 years: A comparison with older patients

Citation
Ga. Stouffer et al., Left main coronary artery disease in adults younger than 50 years: A comparison with older patients, CATHET C IN, 51(1), 2000, pp. 11-17
Citations number
27
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
ISSN journal
15221946 → ACNP
Volume
51
Issue
1
Year of publication
2000
Pages
11 - 17
Database
ISI
SICI code
1522-1946(200009)51:1<11:LMCADI>2.0.ZU;2-U
Abstract
Left main coronary artery (LMCA) disease is a potentially lethal disease th at can be effectively treated if it is recognized expeditiously, To determi ne whether clinical signs and symptoms vary with age, we examined data from 100 patients with angiographically significant LMCA disease (greater than or equal to 50% stenosis), The majority of patients had myocardial infarcti on (32%) or Braunwald class I unstable angina (46%), There were no differen ces in initial symptoms, electrocardiographic findings (normal or only nons pecific changes in 52% of patients), or left ventricular function (normal o r only mildly impaired in 76% of patients) between younger patients (<50 yr ; n = 29) and older patients (n = 71). Severe atherosclerosis was common in both groups. Risk factor profiles were different, however, in that diabete s mellitus (10% vs. 34%; P = 0.028) and hypertension (38% vs, 73%; P = 0.00 2) were less common and tobacco use was more common (79% vs. 39%; P < 0.001 ) in younger patients. In summary, age influenced the risk factors associat ed with but not the clinical signs and symptoms of LMCAD. Cathet Cardiovasc . Intervent. 51: 11-17, 2000. (C) 2000 Wiley-Liss, Inc.