Schnitzler's syndrome: no evidence for autoimmune basis in two patients

We report two cases of Schnitzler's syndrome in which anti-interleukin-1 al pha autoantibodies and functional autoantibodies against the high affinity IgE receptor (Fc epsilon RI alpha) or against IgE were absent. One patient responded well to TL-01 phototherapy, a treatment which may be considered i n patients with Schnitzler's syndrome if, as is usually the case, they are unresponsive to antihistamine therapy.