Gw. Amsden et al., Pharmacokinetic study of azithromycin with fluconazole and cotrimoxazole (trimethoprim-sulfamethoxazole) in healthy volunteers, CLIN DRUG I, 20(2), 2000, pp. 135-142
Background: Azithromycin, fluconazole and cotrimoxazole (trimethoprim-sulfa
methoxazole; TMP/SMX) are all agents that are utilised for the treatment an
d/or prophylaxis of opportunistic infections in patients with AIDS.
Objective: To characterise the potential for an interaction when azithromyc
in is coadministered with cotrimoxazole or with fluconazole.
Design: Two separate nonblind randomised studies were conducted in healthy
volunteers. During the fluconazole study the potential for fluconazole to a
dversely affect the pharmacokinetics of azithromycin was also studied.
Participants: 24 (cotrimoxazole) and 18 (fluconazole) healthy male and fema
le volunteers.
Results: The results of both studies indicated that neither the peak concen
trations of nor the exposures (area under the concentration-time curve) to
the test drugs were changed when azithromycin was coadministered. In additi
on, fluconazole did not significantly alter the pharmacokinetic parameters
of azithromycin.
Conclusions: Azithromycin does not alter the bioavailability of either cotr
imoxazole or fluconazole.