In an unselected, prospective case control study, the incidence of risk fac
tors and perioperative complications was investigated in 237 knees (203 pat
ients) undergoing implantation of cementless total knee endoprostheses. Int
raoperative complications and postoperative complications occurred in 84 pa
tients (99 knees), with 61 specific orthopaedic complications in 50 patient
s (57 knees) and 74 nonsurgical complications in 55 patients (65 knees), Th
e presence of cardiac, neurologic, or psychiatric concomitant diseases, adv
anced age, male gender, high-risk anesthesia scores, number and extent of i
ntraoperative blood pressure fluctuations, and surgery under intubation ane
sthesia are associated significantly with the incidence of nonsurgical peri
operative complications, In contrast, body weight, concomitant metabolic an
d circulatory diseases, previous surgery on the joint, origin of the articu
lar disease, and the duration of surgery and tourniquet time do not correla
te with the probability of a nonsurgical perioperative complication. A sign
ificant correlation with the parameters investigated could not be found for
the occurrence of specific orthopaedic complications. The current report i
dentifies specific risk factors that define patients with risk of having pe
rioperative complications according to objective criteria. These parameters
must be given individual consideration when establishing the indication an
d planning of surgery.