F. Laurent et al., CT-guided transthoracic needle biopsy of pulmonary nodules smaller than 20mm: Results with an automated 20-gauge coaxial cutting needle, CLIN RADIOL, 55(4), 2000, pp. 281-287
AIMS: To evaluate the efficacy and the complication rate of CT-guided percu
taneous lung biopsy of pulmonary nodules smaller than 20 mm in diameter usi
ng a 20-gauge coaxial automated biopsy device. MATERIAL AND METHODS: A pros
pective study was undertaken of 200 patients who underwent 202 consecutive
biopsies of pulmonary nodules, performed with a single type of automated bi
opsy device. Sixty-seven biopsies of nodules smaller than 20 mm in diameter
were performed in 66 patients (group A). One hundred and thirty-five biops
ies of lesions of 20 mm or greater in size were performed in 134 patients (
group B). Patient characteristics, lesion and procedure variables, the accu
racy and complication rates were compared.
RESULTS: In group A, the final diagnosis of the nodules was malignant in 47
and benign in 19 cases (prevalence of malignancy 71.2%). In group B, there
were 111 malignant and 21 benign diagnoses (prevalence of malignancy 82.2%
). In group A, the sensitivity and specificity for a diagnosis of malignanc
y were 89.5 and 100%, respectively (positive predictive value 100%, negativ
e predictive value 76%). A specific diagnosis of benignity was obtained in
nine out of 19 (47%) biopsies. The pneumothorax rate was 15% (10 patients)
of which two (3%) required drainage. CT signs thought to reflect alveolar h
aemorrhage were noted in 28 (43%) and haemoptysis occurred in five patients
(5.9%). In group B, the sensitivity and specificity for a diagnosis of mal
ignancy were 95.5% and 100%, respectively (positive predictive value 100%,
negative predictive value 82.7%). A specific diagnosis of benignity was mad
e in 14 cases (58.3%). Complications included pneumothoraces in 22 cases (1
6.2%) requiring drainage in one (0.7%). Presumed alveolar haemorrhage was r
ecorded in 19 cases (14.1%) and haemoptysis occurred in seven (5.2%). There
were no significant differences between group A and group B, except for al
veolar haemorrhage (P < 0.001).
CONCLUSION: The accuracy and complication rate of percutaneous CT-guided bi
opsy of nodules smaller than 20 mm, performed using an automated 20-gauge c
oaxial biopsy device, are comparable to those for larger lesions. (C) 2000
The Royal College of Radiologists.