IgCAMs: bidirectional signals underlying neurite growth

Authors
Kamiguchi, H Lemmon, V
Citation
H. Kamiguchi et V. Lemmon, IgCAMs: bidirectional signals underlying neurite growth, CURR OP CEL, 12(5), 2000, pp. 598-605
Citations number
71
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN CELL BIOLOGY
ISSN journal
09550674 → ACNP
Volume
12
Issue
5
Year of publication
2000
Pages
598 - 605
Database
ISI
SICI code
0955-0674(200010)12:5<598:IBSUNG>2.0.ZU;2-R
Abstract
Understanding how immunoglobulin superfamily cell adhesion molecules (IgCAM s) regulate nervous system development has lagged behind studies on integri ns and cadherins. The recent characterization of IgCAM structures combined with cell biological studies on protein-protein interactions and membrane t argeting/trafficking demonstrate that IgCAMs interact in exceedingly comple x ways to regulate axonal growth and pathfinding.