The role of chromosomal RNAs in marking the X for dosage compensation

Authors
Kelley, RL Kuroda, MI
Citation
Rl. Kelley et Mi. Kuroda, The role of chromosomal RNAs in marking the X for dosage compensation, CUR OP GEN, 10(5), 2000, pp. 555-561
Citations number
55
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
10
Issue
5
Year of publication
2000
Pages
555 - 561
Database
ISI
SICI code
0959-437X(200010)10:5<555:TROCRI>2.0.ZU;2-K
Abstract
Both flies and mammals remodel the architecture of the X chromosome to achi eve dosage compensation. A novel class of noncoding RNAs that paint entire chromosomes are centrally involved in this process. The genes encoding thes e unusual RNAs are themselves located on the X, and are key sites that targ et the X for dosage compensation.