STUDIES ON CHEMICAL MODIFICATION OF MONENSIN .6. PREPARATION OF C-7 MODIFIED MONENSINS VIA PROTECTED 7-OXOMONENSIN AND EVALUATION OF THEIR ION-TRANSPORT ACTIVITY

Authors
NAGATSU A TABUNOKI Y NAGAI S UEDA T SAKAKIBARA J HIDAKA H
Citation
A. Nagatsu et al., STUDIES ON CHEMICAL MODIFICATION OF MONENSIN .6. PREPARATION OF C-7 MODIFIED MONENSINS VIA PROTECTED 7-OXOMONENSIN AND EVALUATION OF THEIR ION-TRANSPORT ACTIVITY, Chemical and Pharmaceutical Bulletin, 45(6), 1997, pp. 966-970
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
6
Year of publication
1997
Pages
966 - 970
Database
ISI
SICI code
0009-2363(1997)45:6<966:SOCMOM>2.0.ZU;2-X
Abstract
7-Carboxymethylmonensin (3), 7-aminomonensin (4), and 7-oxomonensin (5 ) were synthesized via protected 7-oxomonensin (2), which is expected to be a useful intermediate for the preparation of various monensin de rivatives. Compounds 3-5 exhibited smaller ion transport activity than monensin (1).